Discoloration around the mouth or eyes should also be taken seriously. While lack of sleep or sun exposure can cause changes, abnormally dark, uneven patches in these sensitive areas might be connected to internal issues. When related to cancer, these dark patches often resist normal skin treatments and progress gradually.

Why Does This Occur?

Cancer cells can interfere with normal metabolic processes. They may trigger the release of growth factors that overstimulate skin cells, causing them to multiply abnormally and produce excess pigmentation. While most cases of darkened skin are not caused by cancer, sudden or unusual changes, especially when accompanied by weight loss, fatigue, or digestive problems, should never be ignored.