In their conclusion, the NHS suggests that if you or the person you know develops a rash that is swollen, raised, itchy, blistered or peeling, it could be a sign of a serious allergic reaction. In this case, it will likely need immediate hospital treatment.
In addition, ibuprofen can cause ulcers in the stomach or gut, especially when taken orally in high doses or over a long period. If ongoing use is needed, your doctor may prescribe medication to help protect your stomach.